pentobarbital will lower the level or effect of ethotoin by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Watch.
pentobarbital will reduce the extent or influence of estrogens esterified by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Check Carefully (one)pentobarbital will minimize the level or impact of benzhydrocodone/acetaminophen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Warning when discontinuing CYP3A4 inducers which can be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone could enhance and may lead to most likely fatal respiratory melancholy.
pentobarbital will increase levels of vortioxetine by rising metabolism. Modify Therapy/Keep track of Closely. Take into account rising the vortioxetine dose when coadministered with strong CYP inducers for >14 days; not to exceed 3 instances first vortioxetine dose.
pentobarbital decreases amounts of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with powerful CYP3A4 inducers; these drugs reduce exposure to vandetanib by as much as forty%.
pentobarbital will reduce the level or influence of larotrectinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Contraindicated (1)pentobarbital will lessen the extent or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with solid CYP3A4 inducers can lead to lowered serum concentrations and lack of antimalarial efficacy
Phenytoin and barbiturate blood levels must be monitored more regularly if supplied concurrently; outcome of barbiturates on phenytoin metabolism reported to become variable; sodium valproate and valproic acid seem to lessen barbiturate metabolism; watch barbiturate blood levels and make appropriate dosage adjustments as required
pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers raise fee of toremifene metabolism, reducing the steady-point out focus in serum.
Therapy need to be administered with caution, if in the slightest degree, to patients who will be mentally depressed, have suicidal tendencies, or background of drug abuse
Observe Intently (1)pentobarbital will reduce the more info level or impact of hydrocodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Caution when discontinuing CYP3A4 inducers which have been coadministered with hydrocodone; plasma concentrations of hydrocodone might boost and may end up in most likely deadly respiratory depressionSerious - Use Substitute (one)hydrocodone, pentobarbital.
pentobarbital will decrease the level or impact of loratadine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs.
With therapeutic doses of TCAs, barbiturates improve metabolism and reduce blood concentrations of TCAs.